Dr. Harold Lancer, a Los Angeles dermatologist, told Glamour UK that the muscle atrophy or loss of muscle mass from long-term use of Botox “can cause an indentation in the temple and indentation in the forehead furrow line, which creates a shelf-like droop of wasted muscle.” What’s more, the repeated injections cause trauma to the skin that can lead to scarring, he said.
Also, there’s “filler fatigue,” a thing that happens when you put increasingly more filler under your skin, and it begins to stretch and weighs skin down. New York-based cosmetic facial plastic surgeon Michelle Yagoda told HuffPost, “each time you put more filler in, the pocket expands more, and it becomes a bigger pocket, so it needs more and more filler to keep it expanded.”
As we age, the subcutaneous fat pads in the face shift and decrease. At the same time, collagen production is declining. This is when we start to see hollow spaces and sagging skin. Fillers were designed to restore volume in these areas. Using them too early and stretching the skin will increase the laxity in later years.

Thank you for the article. I am in my early 30’s and my doctor told me to pay upfront for 2 years in advance and to come in every 3 months for botox injections. I think I will pass on his offer.