UVA Medicine On Improving Lung Transplants

Internal Medicine

10 Jan 2024 | 0 | by kjh

2569540login-checkUVA Medicine On Improving Lung Transplants

There’s exciting news at the University of Virginia School of Medicine.  A team of researchers led by Swapnil K. Sonkusare, PhD, has determined that there is potentially a way to improve the success of lung transplants. It involves preventing damage caused when blood flow is restored to the organ.  Swapnil Sonkusare is a member of University of Virginia’s Department of Molecular Physiology and Biological Physics.  He and his team identified a cascade of cellular changes that take place within the lung that ultimately result in what is known as “ischemia-reperfusion injury,” a major cause of organ rejection and death after transplant.

Dr. Victor Laubach from from the University of Virginia’s Department of Surgery collaborated with Swapnil K. Sonkusare.  Doctors may be able to prevent ischemia reperfusion injury by targeting the underlying biological processes that Sonkusare and his team have identified. Ischemia-reperfusion injury is a major cause of what is known as “primary graft dysfunction,” the leading cause of death within 30 days of a lung transplant.

With so many in need of a lung transplant, breakthrough research will help lessen complications in the future.  The research was funded by a grant from the National Institutes of Health.  The findings have been published in the journal, Science Signaling.  To read the published report, visit:

https://www.science.org/doi/10.1126/scisignal.adg1553

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